ISSN 2329-9835
International Journal of Diseases and Disorders ISSN 2329-9835 Vol. 11 (6), pp. 001-004, June, 2023. © International Scholars Journals
Full Length Research Paper
Prevalence of plasmid-mediated quinolone resistance qnr genes in Central China
Xuan Cai, Congrong Li*, Jun Huang and Yan Li
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, People’s Republic of China.
Accepted 7 April, 2023
Abstract
A total of 179 Gram-negative bacteria strains collected in Wuhan from 2005 to 2006 were screened for qnrA, qnrB and qnrS genes by polymerase chain reaction (PCR). The qnrA genes were detected in 3.88% of Escherichia coli and 7.69% of Enterobacter cloacae, whereas the qnrB genes were found in 6.20% of E. coli and 7.69% of E. cloacae. 2.33% of E. coli and 18.92% of Klebsiella pneumoniae were positive for the qnr gene in PCR. Minimal inhibitory concentrations (MICs) results of ciprofloxacin confirmed that qnrS gene could be present in isolates susceptible to quinolones. Furthermore, the results indicated that qnr genes were identified on transferable plasmids, and quinolone resistance can be transferred by bacterial conjugation.
Key words: qnr, gram-negative pathogens, plasmid-mediated.