ISSN 2756-3812
International Journal of Medical Advances and Discovery ISSN 2756-3812 Vol. 1 (1), pp. 001-005, December, 2010. © International Scholars Journals
Full Length Research Paper
Increase activity of serum total and prostatic acid phosphatase in rats exposed to gasoline vapours
*F. E. Uboh, M. I. Akpanabiatu, E. E. Edet and P. E. Ebong
Biochemistry Department, Faculty of Basic Medical Sciences, University of Calabar, P.M.B.1115, Calabar, Nigeria.
Accepted 12 October, 2010
Abstract
In this study, changes in the activities of serum total and prostatic acid phosphatase (TACP and PACP, respectively), alkaline phosphatase (ALP), gamma( )-glutamyltransferase (GGT) and testosterone level were assessed in male rats exposed wholly to 17.8±2.6cm3 hr-1kg-1m-3 day-1 of gasoline vapours (8 hours daily, 6 days/week) for 20 weeks in exposure chambers. The results showed that exposure to gasoline vapours caused a significant increase (P < 0.05) in serum TACP, PACP, ALP, GGT and testosterone levels, by 74.12 ± 4.71, 74.00 ± 2.80, 53.00 ± 3.6, 87.17 ± 2.5 and 83.42 ± 5.2 percents, respectively, in male rats. Increase in serum acid and alkaline phosphatases, - glutamyltransferase and testosterone levels, observed in this study to be associated with exposure of male rats to gasoline vapours, is known to be implicated in various prostatic clinical conditions, including prostatic cancer.
Key words : Gasoline vapours, acid phosphatase, -glutamyltransferase, testosterone.