ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 1 (1), pp. 001-004, December, 2010. © International Scholars Journals
Full Length Research Paper
Cross-linked nanoparticles of cytarabine: Encapsulation, storage and in-vitro release
Nisha Mary Joseph1* and Pramod Kumar Sharma2
1School of Pharmacy, Mekelle University, Mekelle, Ethiopia.
2Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.) India.
Accepted 13 April, 2010
Abstract
This work presents results of the preparation and characterization of nanoparticles for entrapping cytarabine, a chemotherapeutic agent. The particle size analysis indicated a uniform particle size. The study of the release of drug from nanoparticles exhibited a prolonged release profile as studied over a period of 16 hours. The drug release was constant from the 10th to the 16th hours, which showed that the formulation was successful for long-term treatment. The drug entrapment efficiency of the nanoparticles having the same ratio of polymer and drug was about 90.2%. The physical stability of the nanoparticles was good as studied over a period of 4 weeks. These results are promising for producing nanoparticles by entrapping cytarabine, which can be useful for cancer therapy.
Key words: Cytarabine, nanoparticles, in-vitro release, sodium tripolyphosphate.