ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (12), pp. 001-006, December, 2020. © International Scholars Journals
Full Length Research Paper
In vitro assessments of antibacterial potential of Commiphora wightii (Arn.) Bhandari. gum extract
Kalpesh B. Ishnava, Yogesh N. Mahida and J. S. S. Mohan*
Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar-388 120, Gujarat, India.
Accepted 11 October, 2020
Abstract
The potential antibacterial efficacy of guggul gum was checked against six Gram- positive and four Gram-negative bacterial strains. The antibacterial activity was assessed by agar well diffusion and two fold serial broth dilution methods. Gram-positive bacterial strains were found to be the most susceptible organisms compare to Gram-negative towards guggul gum extract once. The minimum inhibitory concentration (MIC) noticed in concentration range of 0.5 - 2 mg/ml. The bioautography was performed to localize active compound present in crude as well as eluted fraction. Compound 5(1-methyl, 1-amino ethyl)-5- methyl-2-octanone, identified which possessed antibacterial activity by various spectrometric method. The extract of guggul gum possesses significant antibacterial activity against Staphylococcus aureus.
Key words: Commiphora wightii, guggul gum, antibacterial activity, bioautography, 5(1- methyl, 1-amino ethyl)-5-methyl-2-octanone.