ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2736-1756 Vol. 19 (4), pp. 001-012, April, 2025. www.internationalscholarsjournals.org/ © International Scholars Journals
Review
Utilizing Transgenic Plants as Bioproduction Systems for Vaccines
B. Vinod Kumar1, T. K. Raja2, M. R. Wani3, S. A. Sheikh3, M. A. Lone3, Gowher Nabi4, M. M. Azooz5, Muhammad Younis6, Maryam Sarwat7 and Parvaiz Ahmad8*
1Department of Microbiology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
2KMR College of Pharmacy, Perundurai – 638052, Tamilnadu, India.
3Department of Botany, GDC Anantnag 192102, Jammu and Kashmir, India.
4Molecular Biology and Genetics Laboratory, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi
Arabia.
5Department of Botany, Faculty of Science, South Valley University, 83523 Qena, Egypt.
6Department of Biochemical Engineering and Biotechnology, IIT, Delhi, Hauz Khas, New Delhi 110016, India.
7Pharmaceutical Biotechnology, Amity Institute of Pharmacy, Amity University, NOIDA, Uttar Pradesh 201303.
8Department of Botany, S.P. College, Srinagar 190001, Jammu and Kashmir, India.
Accepted 23 Jan, 2025
Abstract
Edible vaccine technology represents an alternative to fermentation based vaccine production system. Transgenic plants are used for the production of plant derived specific vaccines with native immunogenic properties stimulating both humoral and mucosal immune responses. Keeping in view the practical need of new technology for production and delivery of inexpensive vaccines, especially in developing world, plant derived edible vaccines is the best option in hand to combat infectious diseases. Plant derived vaccine is easy to administer, cost effective, readily acceptable, have increased safety, stability, versatility and efficacy. Several plant derived vaccines are under research, some are under clinical trials for commercial use. Like most biotechnology products, the IP situation for edible vaccines is complex as IP rights influence every stage of vaccine development.
Keywords: Transgenic plants, edible vaccines, chimeric viruses, bacterial diseases, viral diseases.