ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 6 (12), pp. 001-006, December, 2017. © International Scholars Journals
Full Length Research Paper
Antinociceptive activity of some 1,4-substituted piperidine derivatives using tail flick method in mice
Amirhossein Sakhteman1, Mohammad Sharifzadeh2, Alireza Moradi1, Hamid Nadri1, Kaveh Tabrizian2,3, Massoud Amanlou4, Ali Asadipour5, Kouros Divsalar5, Abbas Shafiee4 and Alireza Foroumadi4,5*
1Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
3Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
4Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
5Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Accepted 13 March, 2017
Abstract
We have examined the potential antinociceptive effects of some piperidine derivatives (6a-f), using tail flick method in mice. Morphine was used as positive control drug. The results showed that compound 6b, having a bromine atom at 4 position, was the most active agent tested. The activity of this compound at 50 mg/kg was comparable to morphine (3 mg/kg). Based on the similarities between our compounds and meperidine like structures such as fentanyl, a group of mice was treated with naloxone before administration of 6f. It was concluded that opioid receptors could be the dominant mechanism for the antinociceptive activity of these types of structures. Electrostatic map, distance analysis and superimposition between fentanyl and compound 6b were also studied.
Key words: Piperidine derivatives, antinociceptive activity, tail flick.