ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 6 (12), pp. 001-005, December, 2017. © International Scholars Journals
Full Length Research Paper
Influence of the aryl substituent identity in 4-arylamino-3-nitrocoumarins on their antimicrobial activity
Vidoslav Dekić1, Niko Radulović2*, Rastko Vukićević3, Biljana Dekić1, Zorica Stojanović-Radić4 and Radosav Palić2
1Department of Chemistry, Faculty of Science and Mathematics, University of Priština, Lole Ribara 29, 38220 Kosovska, Mitrovica, Serbia.
2Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia.
3Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia.
4Department of Biology and Ecology, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia.
Accepted 14 March, 2017
Abstract
Two new and six previously known coumarin derivatives with promising biological properties were synthesized in moderate to good yields by reaction of 4-chloro-3-nitro-coumarin and the appropriate arylamine in ethyl acetate in the presence of triethylamine. The synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against pathogenic strains. A correlation between the aryl substituent identity and antimicrobial activity was discussed.
Key words: 4-Arylamino-3-nitro-coumarins, synthesis, NMR spectroscopy, 4-chloro-3-nitro-coumarin, arylamines, antimicrobial activity.