ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 3 (4), pp. 001-003, April, 2012. © International Scholars Journals
Short Communication
Bilirubin lowering potential of Orthosiphon stamineus in temporarily jaundiced adult rats
Faizah M. Faizul, Norhaniza Aminudin, Habsah A. Kadir and Saad Tayyab*
Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Accepted 09 February, 2012
Abstract
Bilirubin (BR) lowering potential of Orthosiphon stamineus (OS) aqueous extract was evaluated in temporarily jaundiced adult rats. Treatment of these rats with OS aqueous extract for three days reduced the BR level significantly to the normal value. Whereas smaller dose (50 mg/kg body weight) resulted in the reduction in BR level from 2.53 ± 0.16 to 1.12 ± 0.17 mg/dL, higher doses of 500 and 1250 mg/kg body weight were found to be more effective in reducing the BR level from 2.44 ± 0.12 to 0.52 ± 0.12 mg/dL and from 2.67 ± 0.29 to 0.32 ± 0.21 mg/dL, respectively. Therefore, OS aqueous extract can be used to reduce BR concentration to a normal level in jaundiced subjects.
Key words: Orthosiphon stamineus, Misai Kuching, hyperbilirubinemia, jaundice, bilirubin.