African Journal of Medical Case Reports

Full Length Research Paper

The study of association between bacterial vaginosis and cervical intraepithelial neoplasia at Xiangya Hospital (Changsha-Hunan, China)

Mamoudou Camara¹ Yuhong Hang² and Yao Ruojin¹*

¹Department of Obstetrics and Gynecology, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China.

²Department of Obstetrics and Gynecology, Central Hospital of Fengxian, Shanghai, 201400, China.

Accepted 05 April, 2022

Abstract

This study was to explore the relationship between bacterial vaginosis and cervical dysplasia. Vaginal discharge gram stain, liquid-based thinlayer cystoFast test (TCT), human papilloma virus (HPV) types 16, 18 test, colposcopy and directed biopsy were performed among 46 patients with cervical dysplasia served as investigate group and 100 patients with cervicitis served as control group. There was statistically significant increase in the incidence of bacterial vaginosis among cervical dysplasia group (52.18%) compared with control group (10.0%) (P<0.05). Their human papilloma virus (HPV) 16, 18 positive rates were 60.9 and 3% respectively (P<0.05). Human papilloma virus (HPV) types 16, 18 and bacterial vaginosis co-infection incidence were 41.3 and 0% respectively (P< 0.05). Both human papilloma virus (HPV 16, 18) and bacterial vaginosis (BV) negative results were 28.3 and 87.0% (P<0.05). Logistic regression test indicated that human papilloma virus (HPV) 16, 18 and bacterial vaginosis were independent risk factors for cervical dysplasia. Bacterial vaginosis facilitates the infection of HPV type 16, 18 and thus enhances development and progression of cervical dysplasia.

Key words: Bacterial vaginosis (BV), Human papilloma virus types 16, 18 (HPV 16, 18), cervical dysplasia (CIN).