ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 2 (4), pp. 001-006, April, 2011. © International Scholars Journals
Full Length Research Paper
Evaluation of antimicrobial potentials of stem bark extracts of Cochlospermum planchoni
Doughari, J. H.*, El-Mahmood, A. M. and Phillip, B.
Department of Microbiology, School of Pure and Applied Sciences, Federal University of Technology, P. M. B. 2076 Yola, 640002 Adamawa State, Nigeria.
Accepted 09 February, 2011
Abstract
Antimicrobial activity of root extracts of Cochlospermum planchoni against some pathogenic bacteria and fungi were investigated using the filter paper disc diffusion method. Phytochemical studies revealed the presence saponins, tannins, glycosides and aikaloid as phytochemicals. Methanol extracts (40 mg/ml) exhibited the highest activity (16 - 30 mm zone diameter of inhibition, MIC and MBC values 2.5 - 22.5 mg/ml) against the test organisms. Chloroform extracts demonstrated the least activity. The activity of the extracts increased with increase in temperature (4 - 100ºC) and increasing acidity (pH 2.5 - 6), but alkaline pH (pH 10) neither enhanced nor depreciated the activity of the extracts. The plant can be used to source newer antibiotic substances and can be used for the treatment of typhoid fever, dysentery, urinary tract and wound infections and mycotic infections.
Key words: Antimicrobial activity, disc diffusion method, extracts, infections, pathogenic, phytochemicals.