ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 3 (12), pp. 001-005, December, 2012. © International Scholars Journals
Full Length Research Paper
Evaluation of anti-athletic fatigue activity of Schizandra chinensis aqueous extracts in mice
Shehua Cao1*, Huanping Shang1, Weibing Wu2, Jingrong Du3 and Ramesh Putheti4
1East China Jiaotong University, Nanchang City, Jiangxi Province, 330013, P. R. China.
2Shanghai University of Sport, Shanghai City, 200438, P. R. China.
3Survey of Jiangxi Science and Technology Normal University, Nanchang City, Jiangxi Province, 330013, P. R. China.
4Member, American Association of Pharmaceutical Scientists (AAPS), 236-203, Saint David Court, Maryland, USA.
Accepted 16 September, 2012
Abstract
To study the anti-athletic fatigue effects of Schizandra chinensis aqueous extracts (SCAE), Forty Kunming male mice were randomized into 5 groups (CG, LDG, MDG, IHDG and HDG) equally based on body mass after one week adoption. The control group (CG) was given distilled water and LDG, MDG, IHDG and HDG were given various doses of SCAE (15, 30, 50 and 80 mg/kg) for 28 consecutive days, respectively. Swimming time, lactate, blood urea nitrogen (BUN) and hemoglobin (Hb) concentration were measured in the forced swimming treated mice. Results showed that SCAE had significant anti-athletic fatigue effects on mice. It extended the swimming time, increased concentration of the Hb, prevent the increase in lactate and BUN concentrations. In addition, acute toxicity studies revealed that SCAE did not exhibit any toxic symptoms in the limited toxicity evaluation in mice.
Key words: Anti-athletic fatigue, Schizandra chinensis, mice.