ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 2 (3), pp. 001-006, March, 2011. © International Scholars Journals
Full Length Research Paper
Synthesis, antiviral and cytotoxic activities of some novel 2-Phenyl-3-Disubstituted Quinazolin-4(3H)-ones
Periyasamy Selvam1*, K. Babu1, R. Padamraj1, Leentje persoons2 and Erik de Clercq2
1Arulmigu Kalasalingam College of Pharmacy, Krishnankoil-626190.
2Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
Accepted 12 January, 2011
Abstract
The 2-phenyl-benzoxazin-4-ones were condensed with primary amine to form the 2, 3-disubstituted quinazolin-4(3H)-ones. Their chemical structure was elucidated by means of spectral (FT-IR, 1H- NMR, MS) and elemental analysis. The antiviral activity and cytotoxicity of the compounds were tested in HeLa cells (vesicular stomatitis virus, Coxsackie virus B4 and respiratory syncytial virus), HEL cells [herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), vaccinia virus], Vero cells (parainfluenza-3, reovirus-1, Sindbis virus, Coxsackie virus B4 and Punta Toro virus). Among the new derivatives evaluated, specific antiviral activity was noted with compound QAA against vaccinia virus, parainfluenza-3 virus and Punta Toro virus, compound QOPD against HSV-1, HSV-2 and vaccinia virus, and compounds QONA and PD-NFIN against Coxsackie virus B4.
Key words: Quinazoline, antiviral, HSV, vaccinia, sulphanamides.