ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN 2326-7267 Vol. 12 (1), pp. 001-011, January, 2023. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Effects of common daisy (Bellis perennis L.) aqueous extracts on anxiety-like behaviour and spatial memory performance in Wistar albino rats
F. Pehlivan Karaka 1*, A. Karaka 1, H. Co kun2 and A. Uçar Turker1
1Department of Biology, Faculty of Arts and Sciences, Abant Izzet Baysal University, Bolu 14280, Turkey.
2Department of Psychology, Faculty of Arts and Sciences, Abant Izzet Baysal University, Bolu 14280, Turkey.
Accepted 17 November, 2022
Abstract
The effects of aqueous extract of flowers from Bellis perennis on anxiety-like behavior and memory in Wistar rats were tested. Vehicle 20 and 60 mg kg -1 B. perennis groups were performed and the animals were tested by open field and elevated plus maze tests for anxiety-like behaviour and Morris water maze test for spatial memory. In the open field, the high dose of B. perennis administrated rats spent more time at the center, showed less mobility and velocity. In the elevated plus maze, the high dose of B. perennis administrated rats spent more time in the open arms, spent less time in the closed arms, were less mobile, were slower and rotated less frequently. In the Morris water maze, the high dose of B. perennis administrated rats spent more of the time to find the platform. In conclusion, B. perennis may produce biphasic effects on both anxiety-like behaviour and learning performance of the rats.
Key words: Bellis perennis, common daisy, anxiety, sedative, spatial memory.