ISSN 2756-3855
International Journal of Urology and Nephrology ISSN 2756-3855 Vol. 13 (4), pp. 001-007, April, 2025. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Expression Patterns of MUC1 Glycoprotein Across Different Stages of Gallbladder Carcinoma
K. Sanjeev Maurya1, Mallika Tewari1, K. Mahendra Thakur2, Mohan Kumar3, and S. Hari Shukla1*
1Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
2Department of Zoology, Faculty of Science, Banaras Hindu University, Varanasi, India.
3Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Accepted 4 September, 2024
Gallbladder carcinoma is a relatively aggressive and frequently lethal cancer. It is defined as a clinicopathological presentation including a wide spectrum of lethal disease from simple gallstones to dysplasia, to carcinoma in situ and invasive carcinoma. MUC1, a cell surface antigen expressed in glandular epithelia, is overexpressed and aberrantly glycosylated in adenocarcinoma. In this report, the immunohistochemical and immunofuorescence expression of MUC1 was studied in formalin -fixed, paraffin-embedded surgical specimens from patients with gallbladder carcinomas. In T2 tumor, 48.3% cases showed weak expression and 51.7% showed moderate expression. In T3 tumors, expression was weak in 23.1 %, moderate in 46.2% and strong in 30.8% of cases. In T4 tumors, 9.1% cases showed weak, 40.9% moderate and 50% strong expression of MUC1. We have shown that early gallbladder cancer pathology may involve MUC1 in the disease progression. We have defined the localization of expression of the MUC1 genes during GBC development and correlated them with expression and its stage dependent nature.
Key words: Gallbladder carcinoma, metastasis, membrane protein, cancer diagnosis.