ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 3 (2), pp. 149-153, February, 2014. © International Scholars Journals
Full Length Research Paper
Synthesis and bio-chemical investigation of series of Bis-(Aldamine-sugar)
Nagham Mahmood Aljamali*
Chemistry Department, College Education for Women, Kufa University, Iraq.
E-mail: [email protected]
Accepted 06 September, 2013
Abstract
The synthesized compounds in our work are calss of heterocyclic compounds in organic synthetic.In the present study, series of various organic compounds [1-11] were synthesized from anil –arabinose compound, which contain two imine –groups can be react as starting material with other compounds (sodium azide, chloro acetyl chloride, azo compound, thiol, secondary amine, maleic anhydride, primary amine) to produce cyclic and open cyclic compounds from (azitidine , form azane , diazepine , thiazine , diazane , sulfide). This work involved cyclization of imine group in some imine –sugar compounds to heterocyclic compounds several steps such as (condensation, alkylation, addition reactions). A detailed discussion of the structural elucidation of newly synthesized compounds was confirmed by (melting points, elemental analysis C.H.N, FT.IR, H.NMR)–spectra, and antimicrobial study on the Gram –positive and Gram –negative bacteria.
Keyword: Bis-aldamine, aze-imine, bis-azimine, cyclize of sugar, azane-sugar, arabino-imine, cyclize of aldamin.