ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 8 (11), pp. 001-011, November, 2019. © International Scholars Journals
Full Length Research Paper
Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression
Biljana Govedarica1*, Rade Injac2, Rok Dreu1 and Stane Srcic1
1Faculty of Pharmacy, Institute of Pharmaceutical Technology, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.
2Faculty of Pharmacy, Institute of Pharmaceutical Biology, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.
Accepted 13 August, 2019
Abstract
Paracetamol (PAR) crystals exhibit poor compressibility, poor flowability and its tablets show a tendency to cap. To improve the mechanical strength of tablets several kinds of “Paracetamol for direct compression” are present on the market. Current research demonstrated the best tablet properties with coated paracetamol (mass of tablets, diameter, height and mechanical strength, friability RSD<2%). Furthermore, coated paracetamol in combination with both investigated superdisintegrants such as Vivasol® and Polyplasdone® XL-10 shows faster disintegration time and dissolution rate in comparison to paracetamol for direct compression. Eventually, the major advantages of the formulation with coated paracetamol for industrial production are decrease of friability and superiority in terms of flowability, compressibility, quick disintegration and dissolution. Regarding the results, coating of PAR particles is beneficial for the manufacturing of tablets with immediate release.
Key words: Paracetamol, powder, direct compression, immediate release, superdisintegrants.