ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 8 (11), pp. 001-005, November, 2019. © International Scholars Journals
Full Length Research Paper
Antisickling activities of extracts of leaf, seed and seed pod of Garcinia kola Heckel
O. E. Adejumo1*, M. D. Ayoola2, A. L. Kolapo3, V. O. Orimoyegun2 and P. O. Olatunji4
1Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria.
2Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria.
3Department of Microbiology, University of Agriculture, Abeokuta, Nigeria.
4Department of Haematology, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Nigeria.
Accepted 19 September, 2019
Abstract
Garcinia kola has been hitherto speculated as effective in the management of sickle cell disease (SCD). Investigations into the antisickling activities of both crude methanol extracts and the aqueous fractions of the leaf, seed and seed pod of G. kola were carried out using p-hydroxybenzoic acid and normal saline as positive and negative controls respectively. At the tested concentrations of 10.0, 1.0 and 0.1 mg/ml, the leaf extracts exhibited greatest antisickling activity whilst the seed pod had the least antisickling activity. However, it was observed that the activity of methanol extract of the seed pod did not differ significantly (p>0.05) from that of the positive control, p-hydroxybenzoic acid. Results for screened phytochemicals of the investigated parts revealed the presence of saponins, tannins, combined and free anthraquinones. The results infer a preliminary confirmation for the effectiveness and use of Garcinia kola in the management of SCD and its implication in drug development.
Key words: Antisickling activity, Garcinia kola, phytochemicals, sickle cell disease.