African Journal of Immunology Research

African Journal of Immunology Research ISSN 9431-5833 Vol. 5 (9), pp. 411-414, September, 2018. © International Scholars Journals

Full Length Research Paper

The effect of Aloe vera extract on humoral and cellular immune response in rabbit

Ghasem Vahedi¹*, Mehdi Taghavi¹, Amin Kheirollahzade Maleki¹ and Reza Habibian²

¹Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

²Faculty of Veterinary Medicine, Islamic Azad University, Urmia Branch, Urmia, Iran.

*Corresponding author. E-mail: [email protected]. Tel: +98935339777.

Accepted 13 October, 2017

Abstract

Some plant polysaccharides are well known to possess immunostimulatory effects. ALOE VERA possesses confirmed curative or healing actions. The aim of this study was to evaluate the effect of the administration of A. VERA plant extract on cellular and humoral immune response in rabbits. 20 healthy male New Zealand white rabbits were randomly divided into five treatment groups: Groups consisted of: 1)   control  group  (normal  saline);  2)  A.  VERA   control;  3)  vaccine  control;  4)  50  mg  A.  VERA   extract  + vaccine; 5) 150 mg A. VERA extract + vaccine. The used vaccine was for myxomatosis. Blood samples were obtained at four time points: days 0, 7, 14 and 21 of the study. CD⁴⁺ and CD⁸⁺ lymphocytes frequency and serum immunoglobulin concentrations were evaluated. According to the results, oral administration of A. VERA affected the composition of lymphocyte subsets and serum immunoglobulins positively. These findings demonstrated that A. VERA may stimulate both cellular and humoral immune responses after immunization.

Key words: Aloe vera, cellular and humoral immune, immunization, rabbits.