ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 7 (11), pp. 001-005, November, 2018. © International Scholars Journals
Full Length Research Paper
Analgesic activity of angiotensin antagonists
Sekar Indumathy* and Subramanian Kavimani
Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences (A Govt. of Puducherry Institution) Puducherry-605006, India.
Accepted 26 July, 2018
Abstract
Angiotensin Receptor Antagonists (ARAs) are widely used compounds in various cardiovascular disorders like Hypertension, Stroke prophylaxis, Heart failure. In addition, they are approved for the treatment of Diabetic Nephropathy. It is reported to produce analgesia on intracerebro-ventricular administration that could be blocked by naloxone. Angiotensin II has been reported for its pro-nociceptive activity. Angiotensin receptor antagonists block the action of angiotensin II by inhibiting its binding with its receptor hence, they exerts analgesic activity. The analgesic activity of angiotensin antagonists Losartan, Irbesartan and Valsartan evaluated by tail immersion, tail flick and tail clip methods have shown significant increase in basal reaction time. Pentazocine, a kappa receptor agonist exerted a significant analgesic effect (p<0.001). In comparison to control, angiotensin antagonists Losartan, Irbesartan and Valsartan show significant reduction in time for onset of writhing and also number of writhing. The % inhibitions of writhing for Losartan, Irbesartan and Valsartan at a dose of 20 mg/kg were 74, 68 and 73% respectively, whereas Aspirin (100 mg/kg) has 83% inhibition. All the three drugs have shown significant p value (p<0.001) which is comparable to standard control
Key words: Angiotensin antagonist, Losartan, Irbesartan and Valsartan.