ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (9), pp. 001-007, September, 2020. © International Scholars Journals
Full Length Research Paper
Modulatory effect of sweet almond extract on serum lipids, lipid peroxidation and histology of pancreas in alloxan-induced diabetic rats
¹Etim O.E, ²Bassey E.I*, ³Ita, S.O,4 Udonkang, I.C,5 Etim, I. E and 6Jackson, I.L
¹Department of Biochemistry, ²Department of Anatomy, ³Department of Physiology Faculty of Basic Medical Sciences, University of Uyo.
4Department of Pharmaceutics and pharmaceutical technology, 5Department of Pharmaceutical and medicinal Chemistry,6Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo.
Accepted 08 August, 2020
Abstract
The modulatory effects of sweet almond extract on lipid peroxidation, serum lipids, and histology of pancreas in alloxan-induced diabetic wistar rats was studied. Serum lipids and lipid peroxidation levels were determined using appropriate chemical techniques. Total cholesterol (TC) and low density lipoprotein (LDL) activities significantly increased in the diabetic groups of animals treated with 300mg/kg, 400mg/kg and 500mg/kg body weight of sweet almond extract in a dose dependent fashion while high density lipoprotein (HDL) showed a significant (P < 0.05) decrease. Triglyceride (TG), very low density lipoprotein (V L D L) and lipid peroxidation (LP) decreased significantly. Modulatory activity of sweet almond on the histology of the pancreas of diabetic wistar rats treated with 300 mg/kg and 400mg/kg body weight of sweet almond extract was significant and pronounced compared to the untreated diabetic group of animals. There was a corresponding regeneration of acinar cells and the islet cells of Langerhans with prominent nuclei, an indication of restored function. The anti-lipid peroxidation and serum lipid modulatory activities of sweet almond extract shows ability to protect, reduce pancreatic damage and risk of diabetic complication.
Key words: Sweet almond, lipid peroxidation, serum lipids, histology and diabetes.