ISSN 2756-3375
African Journal of Immunology Research ISSN 2343-6549 Vol. 5 (12), pp. 453-462, December, 2018. © International Scholars Journals
Full Length Research Paper
Naturally acquired antibody to DBL5 and ID1-ID2a dynamics in primigravid women during postpartum in a rural setting of Burkina Faso
Ousmane Traoré1,2*, Hermann Sorgho1, W. Isidore Yerbanga1, Toussaint Rouamba1, Guillaume S. Sanou3, Innocent Valea1, Maminata Traoré-Coulibaly1, Susana Scott7, Petra F. Mens5, Henk Schallig5, Yves Traoré4, Adrien M. G. Belem2, Umberto D’Alessandro6 and Halidou Tinto1
1Institut de Recherche en Sciences de la Santé, Unité de Recherche Clinique de Nanoro (IRSS-URCN), Nanoro, Burkina Faso.
2Université Nazi Boni de Bobo-Dioulasso (UNB), Bobo-Dioulasso, Burkina Faso.
3Centre National de Recherche et de Formation sur le Paludisme (CNRFP), Ouagadougou, Burkina Faso.
4Université Ouaga I, Pr Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.
5Department of Medical Microbiology-Parasitology Unit, Academic Medical Centre, Amsterdam, 1105 AZ, The Netherlands.
6Disease Control and Elimination Theme, Medical Research Council Unit, Fajara, The Gambia.
7Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Corresponding author E-mail: [email protected]; Tel. +226 70 58 99 41.
Accepted 30 October, 2018
Abstract
Pregnancy is challenging for women, as their immune system is required not only to protect their body against pathogens, but also to develop an immune tolerance for the foetus growth in utero. However, after delivery little is known about the immunological basis of women susceptibility to malaria infection. The aim of this study was to assess the antibody profiles against VAR2CSA recombinant fragments at delivery and to evaluate their dynamics at 1 and 3 months post-delivery. Sera levels of anti-VAR2CSA antibodies were measured by enzyme linked immunosorbent assay using sera samples collected from primiparous and nulliparous women, using DBL5 and ID1-ID2a domains. Pregnancy background information showed that 51.5% of primiparous women experienced at least one malaria episode during their pregnancy. Placental malaria was diagnosed in 23.8% of women at delivery. Women infected during pregnancy showed higher levels of VAR2CSA-specific antibodies. However, the proportion of seropositive individuals decreased during the follow up period. Malaria infection during pregnancy contributes to establish the specific humoral immunity to placental malaria antigens in women living in endemic areas. The naturally acquired specific antibodies are not boosted by postpartum infections; but rather declines overtime.
Keywords: Antibody, DBL5, ID1-ID2a, postpartum, malaria.