ISSN 2326-7267
International Journal of Pharmacy and Pharmacology Vol. 3 (12) pp. 001-007, December, 2012. © International Scholars Journals
Full Length Research Paper
Halogen substitution anilides of 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylic acid as an attempt of optimization of quinolone diuretics by “me-too” method
Igor V. Ukrainets1*, Igor N. Chernenok1, Nikolai Yu Golik2 and Vera N. Kravchenko3
1Department of Pharmaceutical Chemistry, National University of Pharmacy, Kharkiv 61002, Ukraine.
2 Department of Analytical Chemistry, National University of Pharmacy, Kharkiv 61002, Ukraine.
3 Department of Biology, Physiology and Human Anatomy, National University of Pharmacy, Kharkiv 61002, Ukraine.
*Corresponding author. E-mail: [email protected]
Received 28 August, 2012; Accepted 19 November
Abstract
Using the principles of creating "me-too-drugs" halogen substitution anilides of 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylic acid have been synthesized as potential diuretics. According to the results of biological trials, the substances exceeding the diuretic effect of hydrochlorothiazide in sufficiently less dose have been revealed. It has been shown that like pyrroloquinolines, which were previously studied, 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxamides can also be the base for new highly effective diuretics and are worthy of further research.
Key words: Amidation, anilides, 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides, diuretics, "me-too".