African Journal of Virology Research

African Journal of Virology Research ISSN 2756-3413 Vol. 18 (5), pp. 001-006, May, 2024. Available online at www.internationalscholarsjournals.org © International Scholars Journals

Full Length Research Paper

Cytokine Signatures in Hypoxic Neuroblastoma Cells: Effects of Potentilla anserina L. N-Butyl Extract on SH-SY5Y Cells

Hong-Sheng Gao1,2, Hui-Min Guo2, Yi-Zheng Wang2, Hong Chen2, Yong-Liang Zhang2*, Ling-zhi Li2 and Jing Sun2

1Department of Hygiene, Logistic College of Chinese People’s Armed Police Force, Tianjin, China.
2Tianjin Key Laboratory for Biomarkers of Occupational and Environmental hazard, Tianjin, China.

Accepted 17 January, 2024

Potentilla anserina L. is the root of Chinese cinquefoil herb of the Rosaceae family, and its ethanol extract improves the immunity and exhibits anti-fatigue and anti-hypoxia properties. This study aimed to explore the cytokines expression profiling and the effect of n-butanol extract of P. anserina L. (NP) on the hypoxia cells. The subjects were divided into three groups: control, hypoxia, and intervention (the group treated with the n-butyl extract of P. anserina L. under the condition of hypobaric hypoxia) groups. The results of the experiment showed that NP could down-regulate the expression of the proinflammatory cytokines of hypoxia SH-SY5Y cells and meantime up-regulate the expression of inhibitive cytokines of immune reaction. The cytokines expression profiling can be deduced as a window into hypoxia SH-SY5Y cells, and n-butyl extract of P. anserina L. can significantly protect the cell against the hypoxia induced damage set up in vitro by sodium dithionite.

Key words: Hypoxia, inflammatory cytokines, Potentilla anserina L., sodium dithionite.