ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (6), pp. 001-005, June, 2020. © International Scholars Journals
Full Length Research Paper
Clinicopathologic and epithelial regression study in cutaneous warts of bovines infected by papillomavirus
Rachel Siqueira de Queiroz Simões Marins1*; Prof. Carlos Eurico Pires Ferreira2
1Molecular Virology Laboratory, Virology Department, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil,
2PhD. Microbiology, Animal Health Laboratory, Vet Hospital, State of North Fluminense Darcy Ribeiro University, Rio de Janeiro, Brazil.
Accepted 21 March, 2020
Abstract
Multiple tumor samples were collected from 32 bovines (BOS TAURUS TAURUS x BOS TAURUS INDICUS), of both sexes, bearers of pedunculated cutaneous flat and/or mixed papillomatosis. The samples were fixed in 10% buffered neutral formalin solution and submitted to histothecnique by inclusion in paraffin for hystopatologic analysis and used in the preparation of an autogenous inactivated vaccine for treatment. The objective of the present work is to show the clinical pathological finding and the classic cytomorphologic alterations associated with the infection of bovine papillomavirus and to accompany the epithelial lesion regression after three doses of vaccine. This vaccine program applied was effective not presenting any new injury in the 16 animals vaccined after the experimental period.
KEY WORDS: papillomavirus infection, bovine cutaneous papillomatosis, cytomorphologic alterations, clinicopathologic findings and vaccine.