ISSN 2756-3375
African Journal of Immunology Research ISSN 9431-5833 Vol. 7 (1), pp. 001-005, January, 2020. © International Scholars Journals
Full length research paper
A comparative study of cyclo-oxygenase inhibitors on immune response with special reference to Cox-2 inhibitors
Farhan Ahmad Khan1* and Hitesh Mishra2
Department of Pharmacology, Teerthanker Mahaveer Medical College and Research Centre, Moradabad-244001, India.
Accepted 17 September, 2019
Abstract
The object of this study is to observe the in vivo effect of cyclo- oxygenase-2 (Cox-2) inhibitors on the humoral response after immunization of rabbits with Salmonella typhi antigen. Albino rabbits of either sex were divided into five groups of six animals each and were administered aspirin (100 mg/kg, (BD), p.o), celecoxib (30 mg/kg O.D, p.o), indomethacin (12.5 mg/kg BD, p.o) and etoricoxib (17 mg/kg O.D, p.o) for seven days starting one day prior to immunization with S. typhi antigen (0.5 ml in each thighs), respectively. The antibody titres were measured weekly for a month using Widal agglutination test. The antibody titres in the first week were augmented in all the groups. The response was more marked in treated group as compared to control group. Later on antibody titre fell markedly in the treated groups. Selective Cox-2 inhibitors administration caused higher antibody suppression in comparison to non-selective Cox inhibitors treatment. These findings support that NSAIDs and the new Cox-2-selective drugs have an unsuspected target, the B cell, and attenuate antibody production.
Key words: Non-steroidal anti-inflammatory drugs (NSAIDS), cost, immunomodulators, antibody production.