ISSN 2167-0447
International Journal of Agricultural Sciences ISSN: 2167-0447 Vol. 14 (1), pp. 001-008, January, 2024. © International Scholars Journals
Full Length Research Paper
Ozonation treatment of contaminated aqueous media with hazardous drug molecules
Atoosa Haghighizadeh1 and Omid Rajabi2*
1Department of Research and Development, Dr Rajabi Pharmaceutical Company, Mashhad, Iran.
2Department of Drug and Food control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Accepted 31 October, 2023
Abstract
This study presents results of ozonation of some different aromatic rings of medicines in aqueous solution. The aim of the research was to investigate the influence of ozone on ring cleavage of drug molecules with an aromatic structure. In this regard, phenobarbital, naphazoline, doxycycline, isoniazid and salbutamol were chosen for exposure to ozone gas overnight. It is proved that ozone can attack the OH groups, opening the aromatic ring to form unsaturated acids, aldehydes and linear alkyl/cycloalkyl groups which then appear as stable products. It is suggested that the first step in these reactions includes penetration of ozone at the C-H bond with the formation of a quinone and a subsequent attack of the aromatic ring T-bond system by the ozone with the formation of ozonides. With this process, ozonation can produce simple, biodegradable and less carcinogenic compounds from complex aromatic ones.
Key words: Ozone, aromatic compound, oxidation, toxicity.