ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 4 (11), pp. 001-005, November, 2015. © International Scholars Journals
Full Length Research Paper
Spasmogenic, spasmolytic and antihypertensive activity of Forsskalea tenacissima L.
Syed Wadood Ali Shah1, Samir Kamil1,2, Waqar Ahmad1 and Niaz Ali1*
1Department of Pharmacy, University of Malakand, Chakdara, Dir (Lower) N-W.F.P Pakistan.
2Cellulose and Paper Department, National Research Center, Dokki, Cairo, Egypt.
Accepted 26 May, 2015
Abstract
Crude methanolic extract of Forsskalea tenacissima was screened for possible spasmogenic, spasmolytic and anti hypertensive activities. The extract was studied in isolated rabbit’s jejunum preparations. The extract was also screened for in vivo antihypertensive effect in spontaneous hypertensive Wistar rats. Crude methanolic extract produced spasmogenic activity (15 ± 2% of control, n = 6, p 0.05) at a test dose of 0.1 mg/ml of the cumulative test dose(s) tried as 0.01, 0.03, 0.1, 0.3, 1, 5 and 10 mg/ml. However, at higher dose 5.0 mg/ml, maximum spasmolytic activity was observed (EC50 = 2.7 ± 0.06 mg/ml, n = 6). The extract also produced bradycardiac effects at test doses of 100 and 300 mg/kg. Statistically significant fall in blood pressure (BP) was 19 and 21 mm Hg for test doses of 30 and 100 mg/kg, respectively (p 0.05). Our current work confirms the folkloric uses of F. tenacissima as spasmogenic, antispasmodic (in large doses) and antihypertensive drug.
Key words: Forsskalea tenacissima, spasmogenic, spasmolytic, antihypertensive, EC50 values.