ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 2 (10), pp. 001-005, October, 2011. © International Scholars Journals
Full Length Research Paper
Antisickling properties of the fermented mixture of Carica papaya Linn and Sorghum bicolor (L.) Moench
Cyril-Olutayo Christianah Mojisola1*, Elujoba Adebolu Anthony2 and Durosinmi Muheez Alani3
1Department of Plant Science and Biotechnology, Faculty of Science, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria.
2Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun-State, Nigeria.
3Department of Heamatology and Immunology, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
Accepted 14 July, 2011
Abstract
The antisickling properties of fermented mixture of dried unripe fruit pulp of Carica papaya and dried Sorghum bicolor leaves, mixed in equal proportions in distilled water, was carried out using sodium metabisulphite sickled red blood cells and the result presented. Equal weight of dried C. papaya fruit pulp and S. bicolor leaves were fermented together in distilled water at room temperature and the aque-ous extract obtained and used for antisickling assays. The extract gotten from the materials incubated for 5 days indicated as SP5, was found to have the highest antisickling properties with 93% inhibitory and 84% reversal activities. The concentration of the day 5 extract was further varied. 0.2 ml was found to be the optimum volume of the test extracts.
Key words: Antisickling, reversal, inhibitory, Carica papaya, Sorghum bicolor, sickle cell anaemia.