ISSN 2326-7267
International Journal of Pharmacy and Pharmacology Vol. 1 (3) pp. 034-040, December, 2012. © International Scholars Journals
Full Length Research Paper
Synthesis, structure and analgesic activity of 1-(2-cyanoethyl)- 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydroxy-alkylamides and their derivatives
Igor V. Ukrainets1*, Olga V. Gorokhova1, Xeniya V. Andreeva1 and Galina Sim2
1Department of Pharmaceutical Chemistry, National University of Pharmacy, Kharkiv 61002, Ukraine.
2Department of Pharmaceutical Chemistry, Far Eastern State Medical University, Khabarovsk 680000, Russia.
*Corresponding author. E-mail: [email protected] . Tel: +38-057-7098643.
Received 15 October, 2012; Accepted 10 December 2012
Abstract
The simple methods for obtaining have been suggested and the synthesis of new hydroxyalkylamides of 1-(2-cyanoethyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid and their derivatives has been carried out by alcoholic hydroxyl. The peculiarities of the spatial structure of the given group of substances have been considered by an example of 3-isopropoxypropylamide. The research results of the analgesic activity of all the compounds synthesized are given; they confirm the expediency of searching new painkillers among quinoline-3-carboxamides. According to the results of pharmacological tests for in-depth study recommended (3-chloropropyl)-amide of 1-(2-cyanoethyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid.
Key words: 3-aminopropanenitrile, 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbox-amides, triethyl methanetricarboxylate, analgesia, pain syndrome.