International Journal of Pharmacy and Pharmacology

International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (10), pp. 001-006, October, 2020. © International Scholars Journals

Full Length Research Paper

New and sensitive spectrophotometric method for determination of xipamide in pure and dosage forms by complexation with Fe(III), Cu(II), La(III), UO₂(II), Th(IV) and ZrO(II) ions

Mohamed Gaber, Abdalla M. Khedr*, Ahmed S. El-Kady

Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.

Accepted 10 August, 2020

Abstract

A new, rapid, sensitive and selective method for the spectrophotometric determination of xipamide in pure and dosage forms is proposed. The method is based on the reaction of xipamide with Fe(III), Cu(II), La(III), UO₂(II), Th(IV) and ZrO(II) ions to form stable colored complexes. The formed complexes have maximum absorbance at 500, 390, 335, 445, 325 and 333 nm for Fe(III), Cu(II), La(III), UO₂(II), Th(IV) and ZrO(II), respectively. Optimum conditions for determination, stoichometry and stability of the formed complexes have been determined. Beer's law is obeyed up to concentration range 54.64-1995.75 µg ml^-1 of xipamide with apparent molar absorptivities ranging from 0.43 x 10³-7.20 x 10³ l mol^-1 cm^-1. The proposed method has been applied successfully for the determination of xipamide in pure form and representative pharmaceutical formulations with high precession and good accuracy.

Keywords: Xipamide; Spectrophotmetric determination; Fe(III), Cu(II), La(III), UO₂(II), Th(IV) and ZrO(II); complexation.