ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN 2326-7267 Vol. 10 (1), pp. 001-008, January, 2021. © International Scholars Journals
Review
Resistin as a new molecule
Iclal GEYIKLI1,3* and Muslum AKAN2,3
1Department of Biochemistry and Clinical Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep 27310, Turkey.
2Department of Biochemistry, Graduate School of Health Science, Gaziantep University, Gaziantep 27310, Turkey.
3Department of Biochemistry and Clinical Biochemistry, School of Medicine, Gaziantep University, ahinbey – Gaziantep – Turkey.
Accepted 10 October, 2020
Abstract
Adipose tissue, in addition to storing energy, secretes numerous factors implicated in modulating insulin, sensitivity and energy balance, such as leptin, adiponectin, TNF- and resistin. Resistin, is a hormone that is produced by fatty cells, a recently described adipokine belonging to the cysteine-rich secretory protein family, was originally described as an adipocyte-derived polypeptide that links obesity and insulin resistance in mice. However, in humans, resistin is expressed at very low concentrations in adipose cells, but at high levels in mononuclear leukocytes, macrophages, spleen cells and bone marrow cells. In recent years, several studies have showed that resistin may play a role in cardiovascular disease, diabetes mellitus and also inflammation and process of inflammation – related diseases. This review will summarize the results of studies related with resistin.
Key words: Adipose tissue, resistin, disease.