ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN 2326-7267 Vol. 14 (3), pp. 001-007, March, 2025. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Bioavailability Study of Four Aspirin Brands Marketed in Nigeria: An In Vitro-In Vivo Correlation Analysis
Bamigbola E. A.1*, Ibrahim M. A.2, Attama A. A.3 and Uzondu A. L.1
1Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmacy, Madonna University,
Elele, Rivers State, Nigeria.
2Department of Pharmaceutics and Pharmaceutical Technology, University of Jos, Plateau State, Nigeria.
3Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.
Accepted 30 January, 2025
The study investigated the possibility of developing an in vitro – in vivo correlation for four commercial brands of aspirin tablets using USPXXI rotating basket apparatus and urinary excretion profiles from eight human volunteers. Various dissolution and pharmacokinetic parameters were obtained for all the brands. Significant rank order correlations were observed between all the in vitro dissolution parameters such as percent dissolved at 30 min, dissolution rate constants (k) and time for 50% dissolution (DT50%) and all the in vivo bioavailability parameters such as cumulative amount excreted up to 8 h (E8), maximum excretion rate (dE/dt)max and time for maximum excretion rate (Tmax). However, no correlation could be established between the cumulative amount excreted up to 24 h (E24) and any of the in vitro dissolution parameters. Moreover, statistical analysis showed no significant inter-subject variation among the subjects that participated in the experiments.
Key words: Aspirin tablets, dissolution rate constant, maximum excretion rate, cumulative amount excreted, in vitro-in vivo correlation (IV-IVC).