ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 6 (7), pp. 001-009, July, 2017. © International Scholars Journals
Full Length Research Paper
Activity induced by dihydrotestosterone-dihydropyrimidine derivative on perfusion pressure and coronary resistance in isolated rat heart
Figueroa-Valverde Lauro1*, Díaz-Cedillo Francisco2, Lopez-Ramos Ma1, Garcia-Cervera Elodia1 and Quijano A. Karen1
1Laboratorio de Investigación en Ciencias Biologicas y Farmacoquímica de la Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Campeche, Av. Agustín Melgar entre calle 20 y Juan de la Barrera, Col Buenavista C.P. 24039 Campeche Cam., México.
2Laboratorio de Química Orgánica de la Esc. Nal. de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340.
Accepted 10 March, 2017
Abstract
Experimental and clinical studies suggest that dihydrotestosterone can be associated with changes in blood pressure. In this work, the effects induced by dihydrotestosterone and dihydrotestosterone-dihydropyrimidine on perfusion pressure and coronary resistance were evaluated, in isolated rat heart using the Langendorff flow model. Additionally, the molecular mechanism involved in the activity exerted by dihydrotestosterone-derivative was characterized. The results showed that dihydrotestosterone- dihydropyrimidine [10-9 mM] significantly increase the perfusion pressure (p = 0.005) and coronary resistance (p = 0.006) in isolated rat heart. Additionally, the activity exerted by dihydrotestosterone-dihydropyrimidine on perfusion pressure [109 to 10-4 mM] was blocked in the presence of nefidepine [10-6 mM].These data suggest that activity induced by dihydrotestosterone-derivative on perfusion pressure and coronary resistance is dependent upon its chemical structure. This phenomenon possibly involves the L-type calcium channel activation through a non-genomic molecular mechanism.
Key words: Dihydrotestosterone, perfusion pressure, vascular resistance.