ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (12), pp. 001-005, December, 2020. © International Scholars Journals
Full Length Research Paper
Chemical composition and antioxidant, antimicrobial, antispasmodic activities of the essential oil of Thymus Fallax Fisch. Mey
Ismihan Goze1*, Ahmet Alim2, Senay Akkus Cetinus3, Nedim Durmus4, Nilufer Vural5 and Hamdi Murat Goze6
1Vocational School of Health Services, Cumhuriyet University,TR-58140,Sivas, Turkey.
2Public Health Laboratory, Sivas Health Directorate, TR-58060, Sivas, Turkey.
3Department of chemistry, Faculty of Science and Literature, Cumhuriyet University, TR-58140,Sivas, Turkey.
4Department of Pharmacology, School of Medicine, Cumhuriyet University,TR-58140, Sivas, Turkey.
5Ankara University Biotechnology Institute, Ankara University, TR-06600, Ankara, Turkey.
6Department of Chemical Engineering, Faculty of Engineering and Architecture, Yeditepe University, TR-34755, Istanbul, Turkey.
Accepted 24 February, 2020
Abstract
The aim of this study was to investigate radical scavenging, antimicrobial and antiospasmodic activities in vitro and the composition of Thymus fallax Fisch. Mey. (labiatte) essential oil. The oil of T. fallax was analyzed by the GS-MS method. The sample was subjected to screening for possible antioxidant activity by using 2, 2-diphenyl-1- picrylhydrazyl (DPPH) and -carotene-linoleic acid assays. Antimicrobial activities of the essential oil were determined on 9 micro-organisms using the agar-disc diffusion method. In rat ileum, direct effect of T. fallax essential oil was investigated on spontaneous contractions. GS/MS analysis of the oil resulted in the identification of 18 compounds, representing 92.41% of the oil; carvacrol (46.15%) was the main component. The essential oil exhibited strong antioxidant activity. It has antimicrobial activity on 8 of 9 microorganisms using the agar-disc diffusion method. T. fallax oil exhibited spontaneous contractions in rat ileum at 100% level at 0.1 mg/mL level. The essential oil of T. fallax has a strong antimicrobial, antioxidant, and antispazmodic activities as studied in our laboratory settings. T. fallax may therefore be regarded as a resourceful plant that can be used in the pharmaceutical and food industries.
Key words: Thymus fallax, antioxidant, antimicrobial, anti-spazmodic activity.