ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 6 (3), pp. 001-005, March, 2017. © International Scholars Journals
Full Length Research Paper
17 -estradiol attenuates LPS-induced interleukin-8 production by human peripheral blood monocytes through estrogen receptor- activation
Nipapan Malisorn*, Noppawan P. Morales, Yupin Sanvarinda and Payong Wanikiat
Department of Pharmacology, Faculty of Science, Mahidol University, Ratchathewi, Bangkok, Thailand.
Accepted 09 November, 2016
Abstract
Proper regulation of the immune response is essential for immune homeostasis. Several proinflammatory cytokines released from activated monocytes mediate inflammation, including interleukine-8 (IL -8) which recruits neutrophils to the site of inflammation. 17 -Estradiol (E2) has a direct role in the modulation of the innate immune function and mediates profound effects on immune function of the monocytes. The effects of 17 -E2 are mediated principally by two receptor subtypes, ER and ER ; both are expressed in monocytes. The aim of this study was, therefore, to characterize the estrogen receptor subtypes that mediate the estrogen effects on LPS-activated IL-8 production by human peripheral blood monocytes. 17 -E2 and PPT attenuated the production of IL- 8 by LPS-activated monocytes in a dose-dependent manner and these effects can be reversed by ICI182, 780. These results suggested a role of ER on the attenuating effect of 17 -E2 on IL-8 production by human peripheral blood monocytes.
Key words: Estrogen receptor , monocytes, interleukin 8.