ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (7), pp. 001-007, July, 2020. © International Scholars Journals
Full Length Research Paper
Preparation and evaluation of polymer-clay nanocomposite as an adjuvant in pharmaceutical formulas of tablets containing drugs with low water-solubility
Arídio M. Júnior1, Flávia A. do Carmo1, Lúcio M. Cabral1, Maria Inês B. Tavares2, Ailton de S. Gomes2, Luciano A. M. Grillo3, and Camila B. Dornelas3*
1Faculdade de Farmácia, Centro de Ciências da Saúde (CCS), Universidade Federal do Rio de Janeiro (UFRJ), Ilha do Fundão, Rio de Janeiro, Brasil
2Instituto de Macromoléculas Professora Eloisa Mano (IMA), Universidade Federal do Rio de Janeiro (UFRJ), Ilha do Fundão, Rio de Janeiro, Brasil
*3Escola de Enfermagem e Farmácia (ESENFAR), Campus A. C. Simões, Universidade Federal de Alagoas (UFAL), Tabuleiro do Martins, Maceió, Alagoas
Accepted 09 June, 2020
Abstract
Polymer (PVP K-30) - organophilic clay nanocomposites were prepared, via solution, in which the influence of time from the mixing of the starting materials was studied. With the help of X-ray diffraction techniques (XRD) and Fourier Transform Infrared Spectroscopy (FTIR), it was possible not only to elucidate the formation of polymeric nanocomposites, but also their process of formation, which occur in short spaces of time. The material resulted in a differential combination of substances with different aspects of functionality in Pharmaceutical Technology, and which resulted in favorable results regarding feasibility as an adjuvant in pharmaceutical formulas, helping the bioavailability of pharmaceuticals with low solubility in water, for both immediate release tablets as well as modified release tablets.
Key words: Nanocomposite, PLN, PVP, pharmaceutical formula, tablet