ISSN 2326-7283
African Journal of Internal Medicine ISSN: 2326-7283 Vol. 11 (1), pp. 001-004, January, 2023. © International Scholars Journals
Case Report
Role of antiepileptics in Lesch Nyhan Syndrome
Choudhury Habibur Rasul1*, Khan Golam Mostafa2, Evana Nasrin3
1Professor, Department of Paediatrics, Khulna Medical College and Hospital.
2Assistant Professor, Department of Paediatrics, Khulna Medical College and Hospital.
3Assistant Registrar, Department of Paediatrics Khulna Medical College and Hospital.
Accepted 04 February, 2012
Abstract
Lesch Nyhan Syndrome is an x linked disorder of purine metabolism manifested by mental retardation, hyperuricemia and compulsive self biting. The defect results from enzyme (HPRT) deficiency. There are several neuropsychiatric symptoms depending on the level of HPRT. We present here a boy of 54 months presenting with classical features and treated with three different antilepileptics in successive order. Treatment with Gabapantine had shown significant improvement of neuropsychiatric features in contrast to other antiepileptics.
Keywords: Lesch Nyhan Syndrome, Antiepileptics, Gabapantine.