ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (2), pp. 001-008, February, 2020. © International Scholars Journals
Full Length Research Paper
Biological activity of progesterone-dihydropyridimidine derivative on perfusion pressure and coronary resistance in isolated rat heart
Figueroa Valverde Lauro1*, Guillermo Ceballos-Reyes2, Francisco Díaz-Cedillo3, Abelardo Camacho-Luis4, Maria López Ramos1 and G. Maldonado-Velazquez1
1Laboratorio de Investigación de la Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Campeche, Av. Agustín Melgar, Col Buenavista C. P. 24039 Campeche Cam., México.
2Laboratorio de investigación, área de posgrado de la Escuela de Medicina del Instituto Politécnico Nacional, Plan de san Luis s/n Col. Santo Tomas, México, D. F. C. P. 11340.
3Laboratorio de Química Orgánica de la Esc. Nal. de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpioy Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340.
4Facultad de Medicina de la Universidad Autónoma del Estado de Durango, Dgo, México.
Accepted 15 October, 2019
Abstract
Experimental studies suggest that progesterone can regulate blood pressure. Nevertheless, there is scarce information about the effects of progesterone and its derivatives at cardiovascular level. In addition, to date the cellular site and mechanism of action of progesterone at cardiovascular level is also unclear. In order, to clarify on those phenomena, we evaluated the effects of progesterone and progesterone-dihydropyridimidine derivative on perfusion pressure in isolated rat heart using Langendorff flow model. Our results demonstrated that progesterone- derivative at a concentration of 10-9 mM, significantly increase the perfusion pressure (p = 0.006) and coronary resistance (p = 0.005) in isolated heart. The activity exerted by progesterone-dihydropyridimidine derivative on perfusion pressure [10-9 to 10-4 mM] was blocked in presence of indomethacin [10-6 mM] and PINANE TXA2 [10-6 mM]. These data suggest that activity induced by progesterone-derivative on perfusion pressure and coronary resistance involves the thromboxane A2 (TXA2) synthesis and secretion.
Key words: Progesterone-dihydropyridimidine derivative, Langendorff, perfusion pressure.