ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (5), pp. 001-009, May, 2020. © International Scholars Journals
Review
Antitubercular drug discovery: the molecular modification as promise tool
Luiz Antonio Dutra1, Thais Regina Ferreira de Melo1, Chung Man Chin1, Jean Leandro dos Santos1
Lapdesf–Laboratório de Pesquisa e Desenvolvimento de Fármacos, Departamento de Fármacos e
Medicamentos, Faculdade de Ciências Farmacêuticas – Universidade Estadual Paulista–UNESP,
Rodovia Araraquara Jaú Km. 01, 14801-902, Araraquara, SP, Brazil.
Accepted 05 December, 2019
Abstract
Tuberculosis is a chronic infectious disease caused by etiologic agent Mycobacterium tuberculosis. “It has been reported that rates of incidence is increasing and each year around 8.9-9.9 million new cases are detected”. The current TB therapy presents several problems such as long-term therapy, drug resistance, no-compliance to therapy and few therapeutic sources to treat the disease. The discovery of new drugs safer and more efficient is urgent. The molecular modification is an important tool that allows discovering new compounds that can be win these challenges. In this work, we summarize the main strategies useful to obtain a new anti-tubercular drug.
Keywords: Tuberculosis; antitubercular drugs; new drugs; molecular modification.