ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN 2326-7267 Vol. 13 (1), pp. 001-010, January, 2024. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Impact of monocycle pulses on biomedical systems
Yafang Tan1,2*, Hongchun Yang1,2, Jun Xu1,2 and Xiaolin Yang1,2
1School of Physical Electronics, University of Electronic Science and Technology of China, Sichuan, 610054, China. 2School of Physical Electronics, University of Electronic Science and Technology of China, No.4, Section 2, North Jianshe Road, Chengdu, P. R. China.
Accepted 18 October, 2023
Abstract
Based on multilayer dielectric model, for the spherical biological cell subjected to pulsed electric field (PEF), a simplified equivalent circuit was presented. According to a mathematical analysis of a monocycle electric pulse (MEP), the relationship between a given pulse duration and a center frequency was established and its main energy was concentrated on the center frequency. Thus the transmenbrane potential of external and inner membranes induced by the MEP with various durations was simply calculated by using a harmonic function with different center frequency and the equivalent circuit equations. Furthermore, the threshold electric intensities and window effect of the electroporation with different pulse duration were discussed assuming that the external and inner membranes would breakdown under certain potential values. In view of current difficulty in developing the high peak power PEF devices and the advantage of the MEP in living cell's electroporation effects, an experimental scheme was presented in which a Gaussian pulse was generated by a photoconductive semiconductor switch (PCSS) and a MEP was produced through a Blumlein transmission line (BTL).
Keywords: Monocycle pulse, transmenbrane potential, electric intensity threshold, window effect, monocycle pulse generator.