ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (5), pp. 001-004, May, 2020. © International Scholars Journals
Full Length Research Paper
Pharmacological justification for the ethnomedical use of Datura Stramonium stem-bark extract in treatment of diseases caused by some pathogenic bacteria
M. H. Shagal*, U.U. Modibbo, and A. B. Liman
Department of Chemistry, Modibbo Adama University of Technology, P.M.B. 2076, Yola, Nigeria.
Accepted 11 January, 2020
Abstract
Phytochermical screening and antimicrobial activity of the aqueous and ethanolic extract of the stem-bark of Datura stramonium was carried out. The extraction with the two solvents (water and ethanol) was carried out at room temperature. The phytochemical investigations include saponins, tannins, steroids, alkaloids, flavonoids, phenols and glycosides. The antimicrobial activity was investigation on Staphylococcus aureus, Salmonella typhi, Shigella spp, Eschericia coli, Klebsiella pneumonia and Neisseria gonorrhea. The results revealed the presence of saponins, steroids, alkaloids, and glycosides in both the extracts. Flavonoid was present only in the ethanol extract. The antimicrobial activity revealed that ethanolic extract showed more antibacterial activity than the aqueous extract. It showed some activities against all the tested bacteria except Neisseria gonorrhea. The aqueous extract only showed activity against Staphylococcus aureus.
Keywords: Datura stramonium, alkaloids, Microbes, antimicrobial activity, ethanolphytochemical screening.