ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (9), pp. 001-007, September, 2020. © International Scholars Journals
Full Length Research Paper
In vitro antibacterial, antifungal and cytotoxic activity of three Bangladeshi Bridelia species
Adeeba Anjum1, Mohammad R. Haque1, Mohammad S. Rahman1, Choudhury M. Hasan1, Md. Ekramul Haque2 and Mohammad A. Rashid1,*
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
2Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
Accepted 20 September, 2020
Abstract
The organic soluble extractives of three Bridelia species, B. verrucosa, B. stipularis and B. tomentosa growing in Bangladesh were subjected to screening for antibacterial, antifungal and cytotoxic activities. All extractives showed moderate to strong antimicrobial activity against 13 Gram positive and Gram negative bacterial strains and three fungi where the stem bark of B. tomentosa demonstrated highest inhibition of growth with zone of inhibition of 23.2 mm against Bacillus cereus and 17.5 mm against Candida albicans. The crude extractives of all three plants of Bridelia species exhibited cytotoxic activity against brine shrimp nauplii having significant LC50 and LC90.
Keywords: Antibacterial, antifungal, cytotoxic, bridelia, brine shrimp nauplii.