ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 2 (8), pp. 001-004, August, 2011. © International Scholars Journals
Full Length Research Paper
Anti-inflammatory activity of methanolic extract of Eclipta prostrata L. (Astearaceae)
G. Arunachalam1*, N. Subramanian2, G. P. Pazhani3 and V. Ravichandran4
1PGP College of Pharmaceutical Science and Research Institute, NH-7, Namakkal - Karur Main Road, Namakkal – 637207, Tamilnadu, India.
2Bharathidasan Institute of Technology, Anna University Tiruchirappalli, Tiruchirappalli - 620024, Tamilnadu, India.
3KRS Pallavan College of Pharmacy, Mannur - 602105, Tamilnadu, India.
4Vels College of Pharmacy, Chennai- 600035, Tamilnadu, India.
Accepted 17 April, 2011
Abstract
The methanolic extract of leaves of Eclipta prostrata Linn was investigated for anti-inflammatory activity in albino Wistar rats. The methanolic extract administered by the oral route at a concentration of 100 and 200 mgkg-1 showed the significant dose dependent anti-inflammatory activity in carrageenin and egg white induced hind paw oedema in rats. Anti-inflammatory activity of the tested extract was comparable with that of the standard drug indomethacin (10 mgkg-1) and cyproheptadine (8 mgkg-1) . The results lend support to the traditional use of E. prostrata in the treatment of inflammatory diseases.
Key words: Eclipta prostrate, methanolic extract, albino Wistar rats, anti-inflammatory activity.