ISSN 2756-3375
African Journal of Immunology Research ISSN 9431-5833 Vol. 7 (2), pp. 001-006, February, 2020. © International Scholars Journals
Full Length Research Paper
Study of antivirus, antibacteria and immune functions of Gaoreqing freeze-dried powder
Nian XIN1, Wei LI2, Yu-Juan LI1, Xiao-Ke MA1, Zhen-Ping FU1 and Yan LI1*
1School of Life Science, Beijing Institute of Technology, Beijing 100081, P. R., China.
2The First Hospital of Jilin University, Changchun, 130021, P. R., China.
Accepted 09 September, 2019
Abstract
Gaoreqing freeze-dried powder was effective fraction extracted from Lonicera japonica Thunb., Scutellaria baicalensis Georgi and Forsythia suspense (Thunb.) Vahl. It was confirmed to have certain anti-virus, anti-bacterial effects and immuno-enhancing activities. Cell culture and influenza viral pneumonia model of mouse were used to study its antiviral effect. Plate culture and pathogenic bacteria-infected model in mouse were established to examine its anti-bacterial effect. Carbon particle clearance test and determination of serum hemolysin were done to observe its immune-enhancing effect. The results showed that Gaoreqing had significant effect on inhibiting cytopathic effect induced by various viruses. Compared with virus control group, high and middle dosage groups could significantly decrease the pulmonary index, pulmonary virus hemagglitination titer in influenza viral pneumonia model of mouse (P < 0.01). It showed obvious inhibitory effects on Streptococcus pyogenes, Staphylococcus aureus, pneumococcus and so on. Gaoreqing also had obvious protective effect on mice infected by S. aureus and pneumococcus. In addition, phagocytosis and 50% hemolyzing concentration of mice were obviously reinforced by Gaoreqing (P < 0.05 to 0.01). The results obtained here demonstrated that Gaoreqing had obvious anti-virus and anti-bacterial effects and enhanced immune function in mice.
Key words: Gaoreqing freeze-dried powder, anti-virus, anti-bacterial, immune function.