ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (12), pp. 001-010, December, 2020. © International Scholars Journals
Full Length Research Paper
Acylated triterpenoidal saponins and cytokinins from Gleditsia aquatica
Ehab A. Ragab*, Mohammed Hosny, Hazem A. Kadry and Hassan A. Ammar
Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Accepted 13 October, 2020
Abstract
Two new bisdesmosidic triterpenoidal saponins acylated with one and two monoterpenoid units; aquaticoside A and B (1 and 2), two new cytokinins, aquaticine A and B (3 and 4), and one known cytokinin; adenosine (5), were isolated from the fruits of Gleditsia aquatica. Their structures were established by means of extensive 1D and 2D NMR studies and chemical degradation. Cytotoxicities (ED50) of various extracts and isolated pure saponins (1 and 2), were measured against various tumor cell lines. The isolated pure saponins (1 and 2), showed the most potent cytotoxicities with ovary adenocarcinoma (MDAH 2774, NIH: OVCAR-3), uterus mesodermal tumor (SK-UT-1), skin malignant melanoma (G-361) and colon colorectal adenocarcinoma (LS 174 T) cell lines.
Key words: NMR, acylated triterpenoidal saponins, cytokinins, Gleditsia aquatica.