ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 2 (11), pp. 001-005, November, 2011. © International Scholars Journals
Full Length Research Paper
Gentamicin and erythromycin modify post prandial glucose excursion in New Zealand rabbits
Bello, Shaibu Oricha* and Chika, Aminu
Department of Pharmacology, College of Health Science, Usmanu Danfodiyo University, Sokoto, Nigeria.
Accepted 05 May, 2011
Abstract
The influence of gentamicin and erythromycin on glucose excursion after oral glucose loads was evaluated in twelve New Zealand rabbits, weighting between 1278 and 1861 g. The rabbits were randomized into three equal groups and were given either 5 mg/kg of Gentamicin i.m., 50 mg/kg of Erythromycin per oral or 0.9% Saline. One hour later, all the rabbits were given 2.5 g/kg of glucose per oral in 5 mls of 0.9% saline. Blood glucose levels were determined just before oral glucose loads, then every 1 h for 4 h, using commercial glucometer. Gentamicin pre-treatment significantly increased the peak glucose level (1 h) and significantly reduced the half -life of the rise in glucose level compared to controls. On the other hand, erythromycin pre-treatment caused significant increase in the glucose levels at 3 and 4 h while the peak glucose level (1 h) was not significantly different. The perturbation of glycemic response to glucose load revealed by both drugs may be clinically important in persons undergoing screening for glycemia and patients under care.
Key words: Gentamicin, erythromycin, glucose, insulin, rabbits, kinetics, prandial.