ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 9 (3), pp. 001-007, March, 2020. © International Scholars Journals
Full Length Research Paper
Anti-helicobacter pylori and protective effects of aqueous Fumaria vaillantii L extract in pylorus -ligated, indomethacin- and toxic-induced ulcers in rats
Rifat-uz-Zaman* and Attiq-ur-Rehman
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur-Pakistan.
Accepted 05 October, 2019
Abstract
This paper evaluated anti-ulcer, anti-secretory and anti-helicobacter pylori effects of folkloric medicinal plant, Fumaria vaillantii L, in rats. Different toxic agents; ethanol (80%), NaOH (0.2 mol/L), NaCl (25%) and indomethacin (30 mg/kg, body weight) were used to produce acute gastric ulceration in rats. Anti-secretory studies were undertaken by using pylorus-ligation, Shay rat technique. F. vaillantii L aqueous extract (Aq-FV) was used in three doses (100, 200 and 300 mg/kg bodyweight). Aq-FV was further tested for anti-H. pylori activity. Extract significantly attenuated gastric mucosal damage induced by toxic agents and indomethacin in rats. Aq-FV restored partially mucus secretion in indomethacin model. In pylorus-ligated rats, Aq-FV significantly reduced the basal gastric acid secretion, acidity and ulceration. Aq-FV possesses significant and more potent anti- ulcer and cytoprotective activities against experimentally-induced gastric ulcers in comparison to Omeprazole. Extract showed significant but less potent anti-H. pylori activity in comparison to Clarithromycin. Evaluation agreed with the folkloric use of F. vaillantii L as anti-ulcer and anti-secretory tool.
Key words: Fumaria vaillantii L, cytoprotection, gastric ulcer, gastric secretion, gastric wall mucus, anti-helicobacter pylori.