ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN 2326-7267 Vol. 11 (5), pp. 001-004, May, 2022. © International Scholars Journals
Full Length Research Paper
Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients
Hassan Ahmadvand1*, Amir Majdaldin Amir Javanbakht2 and Hussein Matooriyan Pour2
1Department of Clinical Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
2Department of Dermatology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Accepted 12 May, 2021
The aim of the present study was the evaluation of serum level of lipids and gamma glutamyl transpeptidase (GGT) activities in patients with acne vulgaris undergoing isotretinoin treatment. Forty-four patients, with severe acne or moderate acne (age mean 23 6±6.0 year) who were resistant to conventional treatment were supplemented with 0.5 mg/kg/day of oral isotretinoin for 120 days. This study revealed a significant increase in serum level of cholesterol, triglyceride and GGT activity. The findings of this work showed a number of negative effects of isotretinoin on disturbances in lipid profile and antioxidant status, in acne patients. Therefore, to control abnormalities in lipid profiles and oxidative stress, we recommend further studies to use antioxidant such as vitamin E supplementation in patients using isotertinoin.
Key words: Acne vulgaris, isotertinoin, serum lipid, gamma glutamyl transpeptidase (GGT).