ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 8 (8), pp. 001-006, August, 2019. © International Scholars Journals
Full Length Research Paper
Evaluation of phytochemical and pharmacological properties of Mikania cordata (Asteraceae) leaves
*Zainul D. Karim, Shamsur E. A and Tahmima Ali
Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Accepted 04 January, 2019
Abstract
The ethanol extract of the dried leaves of Mikania cordata (Family-Asteraceae) was investigated for its possible bioactive chemical groups and antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 125 and 250 mg/kg body weight (p<0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The crude extract produced the moderate cytotoxic activity against brine shrimp Artemia salina (LC50=90 and LC90=166 µg/ml). The extract showed antibacterial activity against some types of microorganisms upon which the extract was employed. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.
Key words: Antimicrobial, antinociceptive, asteraceae, cytotoxic, Mikania cordata.