ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 7 (8), pp. 001-005, August, 2018. © International Scholars Journals
Full Length Research Paper
Gastroprotective effects of Stachys Lavandulifolia extract on experimental gastric ulcer
Fatemeh Nabavizadeh1*, Ali Mohammad Alizadeh2, Soheila Adeli1, Masoumeh Golestan1, Hamid Moloudian3 and Mohammad Kamalinejad4
1Department of physiology, Tehran University of Medical Sciences, Tehran, Iran.
2Cancer Research Center, Tehran University of medical sciences, Tehran, Iran.
3Student of pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
4Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Accepted 18 January, 2018
Abstract
Several studies have used Stachys Lavandulifolia vahl (S. lavandulifolia) as medicinal plant in Iranian folk medicine. The present investigation is designed to elucidate therapeutic and preventive effects of S. lavandulifolia extract on gastric acid and pepsin secretions in experimental gastric ulcer. Thirty two Wistar male rats were used to study therapeutic and preventive effects of S. lavandulifolia extract on alcohol-induced gastric ulcer. Animals were equally (n=8) divided into 4 groups: (I) Control (II) Alcohol (1 ml/200 g/bw) to induce gastric ulcer (III) Alcohol/Lvandu (100 mg/kg bw/daily, S. lavandulifolia extract was given for two weeks post alcohol administration) and (IV) Lvandu/alcohol (S. lavandulifolia extract was given for two weeks before alcohol administration). Ulcer index, gastric acid and pepsin secretions was measured. Ulcer index was significantly decreased in alcohol/Lvandu than Alcohol group. Also gastric acid and pepsin secretions, and gastric tissue’s NO metabolites level were significantly lower in alcohol and Lvandu/alcohol groups than control (p<0/05). But changes in gastric acid and pepsin secretions have not been noticeable in alcohol/Lvandu group than control. The results of this study show that S. lavandulifolia extract protected gastric mucosa from alcohol-induced gastric ulcer. This gastroprotection may mediate via gastric mucosal nitric oxide production.
Key words: Stachys Lavandulifolia, acid, pepsin, nitric oxide